Complete Superior Biofilm Destruction (Log >7.3). Read more about this Game-Changing Results
The Terrible Impact of Biofilm
Biofilms prolong inflammation, damage tissues, and disrupt wound healing by evading immune responses, eroding tissues, and resisting antimicrobials, complicating treatment and recovery.
Biofilm in Chronic Wounds
Biofilms are present in over 60-90% of chronic wounds, significantly delaying the healing process.
Rapid Formation
Biofilms can begin forming within 30 minutes to 24 hours of bacterial attachment, quickly establishing a protected environment for microbes.
Healing Time
Wounds with biofilms take up to 100 times longer to heal compared to wounds without biofilms
Antibiotic Resistance
Bacteria in biofilms can be up to 1,000 times more resistant to antibiotics and disinfectants.
Reinfection Rates
After surgical debridement, biofilm regrows within 24-48 hours, leading to recurrent infections and treatment failures.
Healthcare Costs
Treating biofilm-related infections increases wound care costs by over 50%, burdening healthcare systems worldwide.
Mortality Risk
Biofilm-related infections are linked to a higher risk of sepsis and systemic infections, contributing to increased morbidity and mortality.
Superior Biofilm Destruction1
SilverStream offers the highest long-term biofilm destruction efficacy:
- Staphylococcus Aureus (MRSA): >99.9% reduction (Log >3.4) in CFU/cm² within 10 minutes.
- Pseudomonas Aeruginosa: Log ~4 reduction in CFU/cm² within 10 minutes.
- Long-Term Effectiveness: >Log 5 reduction after 55 minutes, and complete biofilm destruction (Log 7.44 for P. aeruginosa and Log 7.32 for S. aureus MRSA) at 6 hours. This ensures continuous protection and healing between dressing changes, minimizing infection risk and promoting faster recovery.
- In Comparison: Normal saline resulted in only a Log ~2 reduction after 6 hours of contact.
SilverStream Action
The Power of Synergy
Each of SilverStream’s components uniquely enhances its synergistic effectiveness.
Ag NO 3 (0.01%)
Preservative & Anti-microbial agent:
Ionic silver kills on contact and inhibits the growth of bacteria, yeast, and fungi
Menthol
Penetration enhancer, Growth promoter, Pain reliever, Odor fighter:
Enhances ionic silver antimicrobial activities and fights wound odor
Promotes granulation tissue growth by vasodilatation
Anti-inflammatory properties, stimulate the antioxidant defense system and promote epithelialization
Glycerol
Soothing agent& a hypertonic aqueous solution that prevents macerations :
Aids mechanical removal of exudates and microorganisms
Creates Hydrogel function by absorbing water molecules and helps to prevent maceration
Tween 20
Surfactant and Detergent:
Enhances solution penetration into the biofilm
Acts as wound-cleansing detergent
Reducing surface tension
Tris Buffer
Maintains a neutral pH balance:
A neutral pH supports cellular activities, such as fibroblast proliferation and collagen synthesis, which are crucial for tissue repair
The Power of Synergy in SilverStream
Synergy is key—SilverStream’s patented, smart formulation combines powerful components to deliver unmatched infection control and accelerated healing.
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Mechanisms of Silver Ions in Targeting Microbial Cells
Silver ions (Ag⁺) are known to play a crucial role in antimicrobial activity and wound healing. Their mechanism includes inducing apoptosis in microbial cells and targeting key cellular processes.
SilverStream effectively utilizes silver ions to disrupt and kill bacterial mitochondria-like systems, ensuring superior infection control.
Interaction with Cellular Membranes
Silver ions bind to thiol groups in membrane proteins, disrupting membrane integrity and increasing permeability. This leads to the leakage of essential cellular contents, compromising bacterial survival.
Generation of Reactive Oxygen Species (ROS)
Silver ions catalyze the production of ROS, causing oxidative stress that damages cellular components, including proteins, lipids, and DNA, ultimately leading to cell death.
Disruption of Mitochondrial Function
Silver ions interfere with the mitochondrial-like systems in bacteria, disrupting energy production and inducing cell death through ATP depletion and loss of membrane potential.
DNA and Protein Interaction
Silver ions penetrate cells, binding to DNA and ribosomal components. This inhibits replication, transcription, and protein synthesis, further impairing microbial functions.
Activation of Caspases
Oxidative stress, mitochondrial disruption, and DNA damage trigger the activation of caspase enzymes. These proteases orchestrate the breakdown of cellular components, leading to programmed cell death (apoptosis).
Inhibition of Key Enzymes
Silver ions inhibit critical enzymes by interacting with active sites, especially those containing thiol groups, disrupting bacterial metabolism and survival.
Silverstream Has Been Tested Against Many Common Pathogens and Multi-Drug-Resistant Bacterial Strains
Tests by leading labs, including Nelson Labs USA, demonstrated 99.999% or greater bactericidal and fungicidal efficacy against pathogens in wound cultures, including those causing skin infections, within 60 seconds, with activity lasting up to 28 days as a preservative.
- Escherichia coli
- Staphylococcus aureus (MRSA)
- Staphylococcus epidermidis
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Anaerobes bacteria
- Candida albicans
- Aspergillus niger
- Trichophyton rubrum
- Microsporum canis
Discover the Proof: Clinical Evidence That Matters
Burns Infected with Staphylococcus Aureus (MRSA)
Electric Burn Patient with Pseudomonas Infection
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References:
1. Evaluation of an Ionic Silver Solution against Dual Species In-Vitro Wound Biofilms: Results of Biofilm Experiments. Center for Biofilm Engineering, Montana USA
2. Use of an Ionic Silver Solution for Wound Cleansing and Reduction in Biomaterial. Thomas E. Serena MD FACS FACHM MAPWCA, St. Vincent Hospital, Erie, PA. USA.
