Safe as OTC, Effective as Rx
Redefining Wound Care for Professionals and Home Use
SilverStream: A Patented Innovation in Wound Care
SilverStream is a patented wound care solution designed to support effective wound cleansing and management. Its innovative formulation utilizes a low concentration of silver nitrate (0.01%), combined with carefully selected complementary ingredients that work synergistically to support the product’s intended performance. By incorporating a low silver concentration, the formulation is designed to maintain effective wound care performance while supporting a favorable safety profile, providing healthcare professionals with an advanced solution for wound management.
Not Just Silver – The Synergy Behind SilverStream Technology
SilverStream technology is more than a silver-based solution. Its patented formulation combines a low concentration of silver nitrate (0.01%) with menthol, glycerol, a surfactant, and a hypertonic buffered environment. These carefully selected components work together to support effective wound cleansing, moisture balance, and the overall performance of the formulation. The formulation is designed to assist in reducing the microbial burden on the wound while supporting an optimal wound healing environment. With a pH close to physiological levels, SilverStream is formulated to be gentle on tissues while maintaining its intended wound care performance.
The Power of Synergy
Every Ingredient Matters: The Synergy Behind SilverStream Technology
Each of SilverStream’s components uniquely enhances its synergistic effectiveness.
| Ingredient | Action | Role in the Formulation |
|---|---|---|
| Ag NO3 | Broad-spectrum antimicrobial preservative | Known for its broad-spectrum antimicrobial activity, ionic silver has been widely used in wound care to help control bacterial, fungal, and yeast contamination. The low concentration used in SilverStream (0.01%) contributes to microbiological stability while remaining well below commonly reported cytotoxic thresholds for topical applications1-3. |
| Menthol | Penetration enhancer Growth promoter Odor fighter Soothing & cooling agent | Known for its cooling sensation and soothing properties, menthol is incorporated as part of SilverStream’s patented synergistic formulation. Published studies suggest that menthol enhance the antimicrobial activity of ionic silver, help reduce wound odor, and provide anti-inflammatory, antioxidant, and vasodilatory effects that may support granulation tissue formation and epithelialization4-8. |
| Tween 20 | Surfactant and Detergent Reducing surface tension | Widely used as a non-ionic surfactant in pharmaceutical formulations, biologics, vaccines, topical products, and wound cleansers, Tween 20 (Polysorbate 20) reduces surface tension, improving solution spreadability, supporting biofilm disruption, and facilitating the mechanical removal of debris, exudate, and microorganisms during wound cleansing. By improving wetting and contact with the wound surface, surfactants may facilitate contact between antimicrobial agents and microorganisms, supporting the overall antimicrobial performance of formulations containing ionic silver, allowing effective performance with low silver concentrations. 7-10. |
| Glycerol | Humectant, osmotic & moisturizing agent | Known for its moisturizing and humectant properties, glycerol helps maintain a moist wound environment while contributing to osmotic management of wound exudate and helping reduce the risk of periwound maceration11-12. |
| Tris Buffer | Physiological pH maintenance | Widely used in pharmaceutical and biotechnology formulations, TRIS (tris(hydroxymethyl)aminomethane) serves as a buffering agent that maintains SilverStream at a near-physiological pH. Maintaining a neutral pH helps preserve an environment favorable for normal cellular activities, including fibroblast proliferation, collagen synthesis, and epithelialization, which are important for tissue repair13. |
| Water for Injection (WFI) | Sterile vehicle | Water for Injection (WFI) is the highest pharmaceutical-grade water used in sterile medicinal products and medical devices. Manufactured under stringent pharmacopeial specifications, WFI is characterized by exceptionally low levels of microbial contamination and bacterial endotoxins. In SilverStream, WFI serves as the sterile carrier for the active and functional ingredients, supporting product purity, formulation stability, and biocompatibility14-15. |
Discover the Difference
Learn more about how SilverStream can transform wound care with superior biofilm destruction and infection control.
Assists in Biofilm Disruption
Biofilm is recognized as a major barrier to wound healing, protecting microorganisms from host defenses and reducing the effectiveness of antimicrobial therapies. SilverStream’s synergistic formulation is designed to assist in biofilm disruption through effective wound cleansing while helping reduce the microbial burden on the wound. The unique combination of ionic silver, Tween 20, menthol, glycerol, and a hypertonic buffered formulation supports wound bed preparation and helps maintain an environment conducive to the natural wound healing process7-10,16.
Addresses Microbial Burden and Supports Formulation Preservation
SilverStream incorporates 0.01% (w/v) ionic silver, which functions as a broad-spectrum antimicrobial preservative, contributing to the microbiological stability of the formulation. In preservative efficacy testing conducted in accordance with USP <51>, the formulation demonstrated excellent activity against representative bacteria, yeasts, and molds. As part of SilverStream’s synergistic formulation, low-concentration ionic silver also supports the reduction of microbial burden during wound cleansing while remaining well below commonly reported cytotoxic thresholds for topical applications.
- Escherichia coli
- Staphylococcus aureus (MRSA)
- Staphylococcus epidermidis
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Anaerobes bacteria
- Candida albicans
- Aspergillus niger
- Trichophyton rubrum
- Microsporum canis
How SilverStream Works
SilverStream is not a silver cleanser – it’s a totally different, all-in-one synergistic liquid wound dressing and irrigation solution that also includes silver ions.
SilverStream is more than a silver solution. It is a multi-component synergistic formulation that combines low-concentration ionic silver with carefully selected complementary ingredients to support effective wound cleansing, moisture balance, and microbial burden management.
Discover the science behind SilverStream’s unique mode of action. The formulation combines ionic silver, menthol, Tween 20, glycerol, TRIS buffer, and Water for Injection (WFI) to support wound cleansing, assist in biofilm disruption, help address microbial burden, maintain a moist wound environment, and preserve a physiological pH. Together, these complementary components create an environment that supports the body’s natural wound healing process while contributing to the microbiological stability of the formulation.
Clinical Insights:
Preparing Wounds for Biologics with SilverStream
SilverStream is not a silver cleanser—it’s a totally different, all-in-one synergistic wound dressing and irrigation solution that also includes silver ions.
In this clinical presentation, Dr. Landsman discusses how SilverStream Solution optimizes the wound bed for biologic therapies-including skin grafts, growth factors, and cellular products. He explains how SilverStream’s multi-component formula promotes granulation, reduces slough and exudate, and improves wound healing outcomes before applying biologic dressings.
Featuring real-life patient cases and practical insights, this video demonstrates the essential role of SilverStream as more than an irrigant—it’s the first step toward regenerative healing.
🎥 Watch now to discover how SilverStream supports innovation in biologic wound care.
About Dr. Adam Landsman
Adam Landsman, DPM, PhD, FACFAS is an Assistant Professor of Surgery at Harvard Medical School and a Podiatrist in the Department of Orthopaedic Surgery at Massachusetts General Hospital. He is Board Certified in Foot Surgery. Previously, he served as Chief of Podiatric Surgery at Cambridge Hospital and directed the Podiatric Research Fellowship at Beth Israel Deaconess Medical Center.
Find more in Data Center
Explore a comprehensive collection of clinical studies, evidence-based data, instructions for use (IFU), brochures, and videos. Dive into the science and solutions behind our innovative wound care products. All resources are at your fingertips to support your knowledge and decision-making.
Reference:
1. Lansdown ABG. A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharmacol Sci. 2010;2010:910686. doi:10.1155/2010/910686.
2. Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: review of the literature. Burns. 2007;33(2):139–148. doi:10.1016/j.burns.2006.06.010.
3. Leaper DJ. Silver dressings: their role in wound management. Int Wound J. 2006;3(4):282–294. doi:10.1111/j.1742-481X.2006.00265.x.
4. Eccles R. Menthol and related cooling compounds. J Pharm Pharmacol. 1994;46(8):618–630. doi:10.1111/j.2042-7158.1994.tb03871.x.
5. Rozza AL, Beserra FP, Vieira AJ, de Souza EO, Hussni CA, Martinez ERM, Nóbrega RH, Pellizzon CH. The use of menthol in skin wound healing—anti-inflammatory potential, antioxidant defense system stimulation and increased epithelialization. Pharmaceutics. 2021;13(11):1902. doi:10.3390/pharmaceutics13111902.
6. Pergolizzi JV Jr, Taylor R Jr, LeQuang JA, Raffa RB. The role and mechanism of action of menthol in topical analgesic products. J Clin Pharm Ther. 2018;43(3):313–319. doi:10.1111/jcpt.12679.
7. Percival SL, McCarty SM, Lipsky B. Biofilms and wounds: an overview of the evidence. Adv Wound Care (New Rochelle). 2015;4(7):373–381. doi:10.1089/wound.2014.0557.
8. Schultz GS, Sibbald RG, Falanga V, Ayello EA, Dowsett C, Harding K, Romanelli M, Stacey MC, Teot L, Vanscheidt W. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen. 2003;11(Suppl 1):S1–S28. doi:10.1046/j.1524-475X.11.s2.1.x.
9. Center for Biofilm Engineering, Montana State University. Evaluation of an Ionic Silver Solution Against Dual-Species In Vitro Wound Biofilms: Results of Biofilm Experiments. Bozeman, MT, USA; 2011.
10. Jung WK, Koo HC, Kim KW, Shin S, Kim SH, Park YH. Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli. Appl Environ Microbiol. 2008;74(7):2171–2178. doi:10.1128/AEM.02001-07.
11. Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008;159(1):23–34. doi:10.1111/j.1365-2133.2008.08643.x.
12. Winter GD. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature. 1962;193:293–294. doi:10.1038/193293a0.
13. Gethin G. The significance of surface pH in chronic wounds. Wounds UK. 2007;3(3):52–56.
14. United States Pharmacopeia (USP). General Chapter <1231> Water for Pharmaceutical Purposes. In: United States Pharmacopeia–National Formulary (USP–NF). Current edition. Rockville, MD: United States Pharmacopeial Convention.
15. European Directorate for the Quality of Medicines & HealthCare (EDQM). European Pharmacopoeia. Monograph 0169: Water for Injections (Aqua ad iniectabilia). Current edition. Strasbourg, France.
16. Dror Y, Ophir C, Freeman A. Silver–enzyme hybrids as wide-spectrum antimicrobial agents. In: Gefen A, ed. Innovations and Emerging Technologies in Wound Care. Elsevier; 2020:293–307. doi:10.1016/B978-0-12-815028-3.00016-X.
